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Alois Alzheimer and the amyloid debate

Nature volume 400, page 810 (1999)Cite this article

Sir

Peter St George-Hyslop and David Westaway discuss the possibility of using Aβ immunization to treat Alzheimer's disease1. They mention the continuing controversy2,3 surrounding the role of extracellular Aβ accumulation and amyloid plaques in the causation of the dementia associated with the disease, referring to this as “an old debate”. What is not widely recognized is how old the question at the centre of this debate actually is.

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References

  1. St George-Hyslop, P. & Westaway, D. Nature 400, 116–117 (1999).

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  2. Hardy, J. H. Trends Neurosci. 20, 154–159 (1997).

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Authors and Affiliations

  1. Department of Neurology, University of Virginia, Charlottesville, 22908, Virginia, USA

    John N. Davis II

  2. Department of Pharmacology and Physiology, University of Rochester, Rochester, 14642, New York, USA

    Jane C. Chisholm

Authors
  1. John N. Davis II
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  2. Jane C. Chisholm
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Davis, J., Chisholm, J. Alois Alzheimer and the amyloid debate. Nature 400, 810 (1999). https://doi.org/10.1038/23571

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