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Infusion of allogeneic-related HLA mismatched mesenchymal stem cells for the treatment of incomplete engraftment following autologous haematopoietic stem cell transplantation

Leukemia volume 21, pages 568–570 (2007)Cite this article

Primary graft failure is rarely observed after autologous haematopoietic stem cell transplantation, and is usually associated with a high mortality despite infusion of back up graft and administration of haematopoietic growth factors.

Mesenchymal stem cells (MSC) are part of the bone marrow microenvironment and support haematopoiesis. In vitro, MSC can differentiate into several tissues1 and possess immunosuppressive properties.2 After intravenous infusion in mice, MSC are detected in a wide range of tissues, including bone marrow,3 and can enhance engraftment of haematopoietic stem cells.4

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References

  1. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000; 6: 1282–1286.

    Article  CAS  PubMed  Google Scholar 

  2. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99: 3838–3843.

    Article  CAS  PubMed  Google Scholar 

  3. Almeida-Porada G, Flake AW, Glimp HA, Zanjani ED . Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Exp Hematol 1999; 27: 1569–1575.

    Article  CAS  PubMed  Google Scholar 

  4. Chapel A, Bertho JM, Bensidhoum M, Fouillard L, Young RG, Frick J et al. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. J Gene Med 2003; 5: 1028–1038.

    Article  PubMed  Google Scholar 

  5. Koç OM, Gerson L, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI et al. Rapid hematopoietic recovery after coinfusion of autologous blood stem cells and culture expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high dose chemotherapy. J Clin Oncol 2000; 18: 307–316.

    Article  PubMed  Google Scholar 

  6. Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK et al. Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and haematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005; 11: 389–398.

    Article  PubMed  Google Scholar 

  7. Ringden O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lonnies H et al. Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease. Transplantation 2006; 81: 1390–1397.

    Article  PubMed  Google Scholar 

  8. Fouillard L, Bensidhoum M, Bories D, Bonte H, Lopez M, Moseley AM et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia 2003; 17: 474–476.

    Article  CAS  PubMed  Google Scholar 

  9. Short B, Brouard N, Occhiodoro-Scott T, Ramakrishnan A, Simmons PJ . Mesenchymal stem cells. Arch Med Res 2003; 34: 565–571.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Haematology and Cell Therapy, Saint-Antoine Hospital, Paris, AP-HP, France

    L Fouillard & N C Gorin

  2. Department of Haematology, Laboratory of Cell Therapy and Accidental Radio Protection (LTCRA, EA 1638), Université Pierre et Marie Curie, Paris 6 and Institute of Radioprotection and Nuclear Safety (IRSN), Fontenay aux Roses, France

    L Fouillard, A Chapel, S Bouchet, P Gourmelon, D Thierry, M Lopez & N C Gorin

  3. Laboratory of Haematology, Henri-Mondor Hospital, Créteil, AP-HP, France

    D Bories & J-M Costa

  4. Etabissement Français du Sang (EFS), Site Henri-Mondor, Créteil, France

    H Rouard

  5. Etabissement Français du Sang (EFS), Paris, France

    P Hervé

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  1. L Fouillard
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  2. A Chapel
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  10. M Lopez
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  11. N C Gorin
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Correspondence to L Fouillard.

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Fouillard, L., Chapel, A., Bories, D. et al. Infusion of allogeneic-related HLA mismatched mesenchymal stem cells for the treatment of incomplete engraftment following autologous haematopoietic stem cell transplantation. Leukemia 21, 568–570 (2007). https://doi.org/10.1038/sj.leu.2404550

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