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MicroRNA losses in the frequently deleted region of 7q in SMZL

Leukemia volume 21, pages 2547–2549 (2007)Cite this article

Splenic marginal zone lymphoma (SMZL) is a recently described B-cell malignancy whose molecular pathogenesis requires further investigation. In contrast with other small B-cell lymphomas, SMZL lacks balanced chromosomal translocations that deregulate the expression of oncogenes like BCL2, CCND1, BCL6 and others. In contrast, around 45% of SMZL cases harbor 7q32 deletions, a chromosomal loss that seems to be quite specific to this particular condition.1 Different expression-profiling studies have identified a set of genes that are potentially involved in SMZL pathogenesis, such as TCL1A, AKT1 and others belonging to the BCR downstream signaling and NF-kB activation pathway.2, 3 Nevertheless, the precise mechanism and role of these genes and pathways have not been fully clarified.

The most distinctive molecular alteration identified in SMZL seems to be the loss of the 7q32 region, which, in some cases, occurs in both alleles. The presence of this recurrent abnormality suggests that this region may contain a novel, and as yet unidentified, tumor-suppressor gene. The minimal common deleted region (CDR) in 7q is confined to 7q32.4 Strikingly, this area contains a high density of microRNAs (miRNAs), which are gene expression regulators that not only have been described as being involved in crucial biological processes, including development, differentiation, apoptosis and proliferation control, but also have been proposed as contributing to oncogenesis, either as tumor suppressors or as oncogenes (reviewed by Calin and Croce5).

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Acknowledgements

We thank the skilled assistance of Lydia Sanchez (CNIO) with the immunohistochemical studies, and Yolanda Vicente (HVS) (CAO6/0006) for their excellent technical support. This work was partially supported by grants from the Ministerio de Ciencia y Tecnología (SAF2004-04286, SAF2005-00221), Fundación La Caixa, Ministerio de Sanidad y Consumo (FIS PI052621, FIS PI051623, INT06/062), Servicio de Salud de Castilla la Mancha (SESCAM #06047-00), and Consejería de Sanidad de la Junta de Comunidades de Castilla-La Mancha (#02031), Spain.

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Authors and Affiliations

  1. Department of Genetics and Pathology, Hospital Virgen de la Salud (HVS), Toledo, Spain

    E Ruiz-Ballesteros, M Mollejo, M Mateo, P Algara & P Martínez

  2. Molecular Pathology Programme, Centro Nacional de Investigaciones Oncologicas (CNIO), Madrid, Spain

    M A Piris

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  1. E Ruiz-Ballesteros
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  2. M Mollejo
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  3. M Mateo
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  4. P Algara
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  5. P Martínez
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  6. M A Piris
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Correspondence to E Ruiz-Ballesteros.

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Ruiz-Ballesteros, E., Mollejo, M., Mateo, M. et al. MicroRNA losses in the frequently deleted region of 7q in SMZL. Leukemia 21, 2547–2549 (2007). https://doi.org/10.1038/sj.leu.2404853

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