Abstract
Storey and co-workers1 claim that there is an association between a common variant of the p53 tumour-suppressor gene and the development of invasive cervical carcinoma. Here we present evidence to refute this, based on a reassessment of the importance of the polymorphism at codon 72 in the p53 gene for the development of cervical cancer.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Storey, A. et al. Nature 393, 229–234 (1998).
Ylitalo, N. et al. (in the press).
Lindqvist, A. K. et al. Genome Res.6, 1170–1176 (1996).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Josefsson, A., Magnusson, P., Ylitalo, N. et al. p53 polymorphism and risk of cervical cancer. Nature 396, 531 (1998). https://doi.org/10.1038/25037
Issue date:
DOI: https://doi.org/10.1038/25037
This article is cited by
-
Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study
BMC Cancer (2019)
-
Lung cancer risk in relation to TP53 codon 47 and codon 72 polymorphism in Bangladeshi population
Tumor Biology (2014)
-
The Discrepancy Between Genetic Polymorphism of p53 Codon 72 and the Expression of p53 Protein in Helicobacter pylori-Associated Gastric Cancer in Korea
Digestive Diseases and Sciences (2010)
-
Detection of human papillomavirus DNA and p53 codon 72 polymorphism in prostate carcinomas of patients from Argentina
BMC Urology (2005)
-
Polymorphism at Codon 72 of p53 Is Not Associated with Cervical Cancer Risk
Modern Pathology (2000)
