Abstract
Bortolotto et al. reply — Nicoll et al. challenge our finding that kainate receptors are involved in mossy-fibre LTP in the hippocampus1. Their argument is based on a discrepancy of our results with earlier work, as we show (our Fig. 5)1 that two kainate-receptor antagonists, kynurenate and CNQX, can also block mossy-fibre LTP. We do not dispute that it may be possible to induce mossy-fibre LTP in the presence of kainate-receptor antagonists under certain conditions. For this reason, we neither stated nor implied that activation of kainate receptors is always necessary for mossy-fibre LTP1.
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References
Bortolotto, Z. A. et al. Nature 402, 297–301 (1999).
Vignes, M. et al. Neuropharmacology 37, 1269– 1277 (1998).
Grover, L. M. & Teyler, T. J. Nature 347, 477–479 (1990).
Bortolotto, Z. A., Bashir, Z. I., Davies, C. H. & Collingridge, G. L. Nature 368, 740–743 ( 1994).
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Bortolotto, Z., Clarke, V., Delany, C. et al. reply: Kainate receptors and synaptic plasticity. Nature 406, 957 (2000). https://doi.org/10.1038/35023077
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DOI: https://doi.org/10.1038/35023077
