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Cell division

Counting on EGFR

Nature Reviews Molecular Cell Biology volume 2, page 233 (2001)Cite this article

Baker and Yu focused on a group of cells that form late in the eye disc. By forming mutant clones within a wild-type tissue, they found that spitz, the ligand for EGFR, is important for division. Looking at different markers for cells that have entered the cell cycle, they then showed that the cells were arrested in G2.

This led them to wonder whether EGFR is required for G2/M progression. As suspected, EGFR mutant clones did not enter mitosis. Using EGFR overexpression, they then confirmed that autonomous EGFR is sufficient to trigger division.

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ORIGINAL RESEARCH PAPER

  1. Baker, N. E. & Yu, S.-Y. The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell 104, 699–708 ( 2001)

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  1. Alison Schuldt
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Schuldt, A. Counting on EGFR. Nat Rev Mol Cell Biol 2, 233 (2001). https://doi.org/10.1038/35067061

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