Figure 8
Histology and immunohistochemistry of tissue recombinants of NeoTag2 cells before and after 2 days and 2 weeks castration. (a, d, g, j) are intact grafts; (b, e, h, k) are grafts from 2 days castration; (c, f, i, l) are grafts from 2 weeks castration. (a–c) Show H&E results. Immunohistochemistry was used to determine AR (d–f), T-antigen (g–i) and CK8 ((j–l) expression before and after castration. (a–c) Prostatic adenocarcinoma with pleomorphic complex cells invading into stroma with high mitotic rate. Comparing (a, b and c, b) shows increased apoptosis with decreased cytoplasm in glandular profiles with associated prominent stroma. (c) Shows decreased apoptosis and atrophic glandular cells. Bars, 50 μm.
