Table 3 Enhancement of Mitogenic Activity of Human VSMC by Products of Hydrolysis of Lipoproteins

From: Mitogenic Effect of Lipoproteins on Human Vascular Smooth Muscle Cells: The Impact of Hydrolysis by gr II A Phospholipase A2

Agent

n

Control cpm/well

Agent cpm/well

p

Lyso PtdChol (20 μm)

5

3233 ± 587

5296 ± 1054

<.05

(30 μm)

2

3019 ± 516

5766 ± 858

<.01

Linoleic acid (10 μm)

5

3389 ± 683

5358 ± 680

<.01

(20 μm)

3

3895 ± 468

4922 ± 813

<.05

Oleic acid (10 μm)

2

3410 ± 755

7001 ± 1500

<.01

(20 μm)

2

4216 ± 312

7271 ± 814

<.01

(30 μm)

3

3565 ± 729

9451 ± 2589

<.01

Lyso PtdChol + linoleic acid (20 μm) + (10 μm)

3

3464 ± 750

7837 ± 1254

<.01

Lyso PtdChol + oleic acid (20 μm) + (10 μm)

3

3464 ± 750

10411 ± 1638

<.01

  1. Incubation time of VSMC with various agents, 4 hours. The difference between lyso PtdCho + linoleic acid and lyso PtdCho alone, p = .011, and with linoleic acid alone, p = .012. The difference between lyso PtdChol + oleic acid and lyso PtdCho alone, p = .003, and with oleic acid alone, p = .003.
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