Table 1 Number (percentage) of melanocytic tumors expressing different levels of (a) p-p38 and (b) p-JNK in the cytoplasm only, nucleus only and both cytoplasm and nucleus

From: Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma

Tumor type

No. of tumors examined

Total no. of positive

p-p38 in cytoplasm only

p-p38 in nucleus only

p-p38 in cytoplasm and nucleus

(a) p-p38

Primary melanomas

152

38 (25)

19 (13)

10 (7)

9 (6)

Superficial spreading

94

24 (26)

15 (16)

6 (7)

3 (3)

Nodular

58

14 (24)

4 (7)

4 (7)

6 (10)

Metastases

68

6 (9)

2 (3)

3 (5)

1 (1)

Benign nevi

27

2 (7)

1 (4)

1 (4)

0 (0)

Tumor type

No. of tumors examined

Total no. of positive

p-JNK in cytoplasm only

p-JNK in nucleus only

p-JNK in cytoplasm and nucleus

(b) p-JNK

Primary melanomas

154

54 (35)

10 (6)

32 (21)

12 (8)

Superficial spreading

93

29 (31)

8 (9)

13 (14)a

8 (9)

Nodular

61

25 (41)

2 (3)

19 (31)a

4 (7)

Metastases

73

18 (25)

4 (6)

10 (14)

4 (6)

Benign nevi

34

25 (74)

0 (0)

25 (74)

0 (0)

  1. aActivated JNK in the nucleus was more frequently observed in nodular melanomas than in superficial spreading melanomas (P=0.042).
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