Table 3 Relationship between activated JNK in the cytoplasm and depth of tumor growth of primary melanomas

From: Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma

Tumor type

Marker

Immunhistochemistry

Depth of growth (mm) c

P

  

Expression type a

No. of patients b

  

Superficial spreading

p-JNK

Negative

74

1.68

0.017

  

Positive

16

2.58

 

Nodular

p-JNK

Negative

54

4.69

0.477

  

Positive

6

3.48

 
  1. aExpression level was scored as described in ‘Materials and methods’.
  2. bTumor thickness was available for 150 patients (90 superficial spreading melanomas and 60 nodular melanomas).
  3. cMeasured as the mean thickness in each group.
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