Modern Pathology

Table 4 Relationship between expression of cytoplasmic and nuclear (a) p-p38, cell cycle markers, p-ERK1/2, p-Akt and p-JNK in primary melanomas and (b) p-JNK, cell cycle markers, p-ERK1/2, p-p38 and p-Akt in primary melanomas

From: Activation of c-jun N-terminal kinase is associated with cell proliferation and shorter relapse-free period in superficial spreading malignant melanoma

(a)
Type of lesions	No. of tumors analyzed	Immunohistochemistry		Expression of p-p38
		Marker	Expression level	Low	High	P
				Cytoplasmic expression
Superficial spreading	94	p-ERK cyt^a	Low	42	1	<0.0005
			High	34	17
	90	p-Akt cyt^a	Low	27	2	0.047
			High	45	16
	89	p-JNK cyt^a	Low	63	10	0.003
			High	8	8
Nodular				Cytoplasmic expression
	58	p-JNK cyt^a	Low	86	6	0.057
			High	41	8
				Nuclear expression
	54	Ki-67	Low	25	0	0.012
			High	22	7
	55	p-TrkA cyt^a	Low	26	2	0.078
			High	20	7
	55	p-TrkA mem^b	Low	32	2	0.02
			High	14	7

(b)
Type of lesion	No. of tumors analyzed	Immunohistochemistry		Ekpression of p-JNK
		Marker	Expression level	Low	High	P
				Cytoplasmic expression
Superficial spreading	86	Cyclin A	Low	52	6	0.017
			High	19	9
	86	Cyclin D3	Low	59	9	0.075
			High	12	6
	86	Ki-67	Low	58	9	0.088
			High	13	6
	56	p21^WAF/CIP1	Low	29	4	0.021
			High	14	9
	96	p-ERK cyt^a	Low	39	2	0.005
			High	38	14
Nodular				Cytoplasmic expression
	55	Cyclin D3	Low	29	1	0.082
			High	20	5
				Nuclear expression
	57	p-Akt cyt^a	Low	13	2	0.059
			High	24	18

^aCytoplasm.
^bMembrane.
Expression levels of cyclins A, D3, p21^WAF1/CIP1, p-ERK½, p-Akt and p-TrkA were scored as described in ^{20, 21, 22, 23, 24, 25}.
Expression levels of cyclin A and Ki-67, cyclin D3, p21WAF/CIP1, p-ERK1/2 and p-Akt were scored as described in Florenes et al,^{21, 25} Maelandsmo et al,²² Jorgensen et al²³ and Slipicevic et al.²⁴

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