Abstract
We do not consider that our inferences about FLASH function are misleading because they were deduced from functional analyses1. We originally identified the death-effector domain (DED)-binding activity of the DED-recruiting domain (DRD) of FLASH before analysing the structural homology between the DED and DRD domains. Moreover, we deduced the self-association activity of FLASH through its central region from functional analysis of several deletion mutants of mouse FLASH. We note that self-association activity of CED-4-homologous proteins is required for the activation of caspases2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Imai, Y. et al. Nature 398, 777–785 (1999).
Walker, J. E. et al. EMBO J. 1, 945–951 (1982).
Yang, X., Chang, H. Y. & Baltimore, D. Science 281, 1355–1357 (1998).
Muzio, M. et al. Cell 85, 817–827 (1996).
Irmler, M. et al. Nature 388, 190–195 (1997).
Itoh, N. et al. Cell 66, 233–243 (1991).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kimura, T., Imai, Y. & Yonehara, S. Searching for FLASH domains. Nature 401, 662–663 (1999). https://doi.org/10.1038/44320
Issue date:
DOI: https://doi.org/10.1038/44320
