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Immunology

Egocentric pre–T–cell receptors

Nature volume 467, pages 793–794 (2010)Cite this article

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The T-cell receptor on the surface of T cells requires antigen recognition to function. Structural studies reveal that its predecessor, the pre-T-cell receptor, is much more independent. See Letter p.844

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Figure 1: Receptor evolution.

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  1. Bernard Malissen and Hervé Luche are at the Centre d'Immunologie de Marseille Luminy, INSERM, CNRS, Université de la Méditerranée, Parc Scientifique de Marseille Luminy, Case 906, 13288 Marseille Cédex 9, France. bernardm@ciml.univ-mrs.fr ,

    Bernard Malissen & Hervé Luche

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  1. Bernard Malissen
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  2. Hervé Luche
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Malissen, B., Luche, H. Egocentric pre–T–cell receptors. Nature 467, 793–794 (2010). https://doi.org/10.1038/467793a

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  1. Jose Ordovas-Montanes

    I would just like to comment on the concluding sentence and bring to the attention of the authors that there is already very suggestive evidence that the pre-B-cell receptor is also functioning through ligand-independent dimerization. (1) This was published this year in Nature Immunology and describes a role for which binding of surrogate light chain to a glycosylation residue present only on uHC can mediate autonomous cross-linking of the BCR and delivery of survival signals.

    1. Ubelhart, R., et al. (2010). N-linked glycosylation selectively regulates autonomous precursor BCR function. Nature Immunology. 11: 759-766.

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