Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Technology Feature
  • Published:

A simpler twist of fate

Ways to directly convert one mature cell type into another may eventually offer a safer, faster strategy for regenerative medicine.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  2. Tapscott, S. J. et al. Science 242, 405–411 (1988).

    Article  CAS  ADS  Google Scholar 

  3. Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).

    Article  CAS  ADS  Google Scholar 

  4. Rackham, O. J. L. et al. Nature Genet. 48, 331–335 (2016).

    Article  CAS  Google Scholar 

  5. Du, Y. et al. Cell Stem Cell 14, 394–403 (2014).

    Article  CAS  Google Scholar 

  6. Cahan, P. et al. Cell 158, 903–915 (2014).

    Article  CAS  Google Scholar 

  7. Zhang, M. et al. Cell Stem Cell 18, 653–667 (2016).

    Article  CAS  Google Scholar 

  8. Cao, N. et al. Science http://dx.doi.org/10.1126/science.aaf1502 (2016).

Download references

Author information

Authors and Affiliations

Authors

Related links

Related links

Related links in Nature Research

Brain cells made from urine

Stem cells: Reprogramming finds its niche

Stem cells: Reprogramming in situ

Diabetes forum: Extreme makeover of pancreatic α-cells

A predictive computational framework for direct reprogramming between human cell types

Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq

Nature subject area page for stem cells

Nature Insight: Stem Cells

Related external links

Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency

Cell Stem Cell Collection on Direct Reprogramming

Generation of induced neurons via direct conversion in vivo

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Eisenstein, M. A simpler twist of fate. Nature 534, 421–423 (2016). https://doi.org/10.1038/534421a

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/534421a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing