Personalized medicine articles from across Nature Portfolio

Patterns in continuous data from wearable devices could reveal early metabolic dysfunction long before routine clinical tests detect it.

This study analyses whole-genome sequencing data of cancer samples from 10,983 patients and explores relationships among mutational signatures, various biomarkers and clinical outcomes.

Type 2 diabetes and hypertension often co-occur, suggesting shared biological mechanisms. Here, Pascat et al. use partitioned polygenic scores to show distinct biological processes link both conditions and improve risk prediction.

A multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human populations.

Launched in 2024, the Canadian Precision Health Initiative will amass Canada’s largest human genomic dataset, including genomes of Indigenous peoples. Our analysis reveals how its structure and governance constrain Indigenous sovereignties within Canadian genomics and precision health efforts.

Patterns in continuous data from wearable devices could reveal early metabolic dysfunction long before routine clinical tests detect it.

Six pregnant women participated in a small trial in which placenta-derived stem cells were applied to fetal spinal cords and the treatment was found to be safe.

Single-nucleus DNA sequencing analyses elucidated the heterogeneous evolution of the genomes of pancreatic cancer cells. The key features uncovered highlighted mechanisms of resistance to therapy that might support ongoing precision medicine efforts.

Amid growing geopolitical tension and scientific advances, fragmented and reactive governance policies could increase the risks of dual-use genomics, undermining international collaboration and data security. This Comment calls on the international genomics community to meet to establish robust, harmonized standards to safeguard genomic data.

In a world first, a bespoke gene-editing therapy benefited one child. Now researchers plan to launch a clinical trial of the approach.