Figure 3
From: The circadian mutation PER2S662G is linked to cell cycle progression and tumorigenesis
High-dose PER2 results in resistance to apoptosis induced by X-rays. (a) Low-, middle- and high-copy PER2 mice were irradiated with 6 Gy X-rays at ZT 9. Spleen cells were isolated 6 h after irradiation and the DNA content was analyzed by flow cytometry. One representative experiment is shown. (b) Percentages of apoptotic cells detected by flow cytometry from low-, middle- and high-copy BAC transgenic spleens (***P<0.001; one-way ANOVA followed by Dunnett's test)
