Figure 4
From: The circadian mutation PER2S662G is linked to cell cycle progression and tumorigenesis
Dysregulation of PER2 increases formation of oncogenic E1A–RAS-mediated foci in MEFs. (a) and (c) Passage 0 MEFs with the indicated genotypes were infected with retroviruses encoding E1A–RAS. Transfections with empty virus vector were used as negative controls. Two representative culture plates are shown per genotype from at least two repeated independent experiments. (b) and (d) The numbers of foci per 60-mm plate in the assays are expressed as means±S.D. (N=6 for each group; one-way ANOVA followed by Dunnett's test)
