Figure 8
From: PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation
Histological and immunohistochemical analysis of skeletal muscles from PED/PEA-15 transgenic mice. Sections from skeletal muscles (tibialis anterior) from 6-month-old transgenic mice and non-transgenic littermates (control; WT) were stained with either hematoxylin-eosin (H/E; a and b) or engel-trichrome (c) or immunostained with LC3 or Beclin1 (BECN1) antibodies (d, e). The arrows in the microphotographs (40 × ) indicate atrophic muscle fibers with basophilic cytoplasm (a), small rimmed vacuoles (b), vacuoles with red inclusions (c), decoration with LC3 (d) and Beclin1 (BECN1; e) antibodies. The microphotographs shown are representative of findings observations in six transgenic and eight non-transgenic animals
