Figure 3 | Cell Death & Differentiation

Figure 3

From: Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

Figure 3

Exacerbated SLE-like disease development in AC-overloaded CD300f-deficient mice. (a) Photographs of spleens isolated from Cd300f+/+ or Cd300f −/− mice treated with pristane alone, or pristane with AC. (b,c) Spleen weight (b) and total number of splenocytes (c) from Cd300f+/+ or Cd300f −/− mice treated with pristane alone, or pristane with AC. (d) The ANA levels in Cd300f+/+ or Cd300f −/− mice treated with pristane and AC were determined by staining of fixed HEp-2 cells. (e) The serum levels of anti-dsDNA IgG in Cd300f+/+ or Cd300f −/− mice treated with pristane and AC were measured by ELISA. (f) Serum cytokine levels were determined for Cd300f+/+ and Cd300f −/− mice treated with pristane and AC using a CBA kit and flow cytometry. Data are the mean+S.E.M. of 5–6 mice per strain. Each symbol in graphs shown in b–e represents a mouse. Asterisks in b–f indicate statistical significance (*P<0.05, **P<0.01, ***P<0.005)

Back to article page