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Expanded ENCODE delivers invaluable genomic encyclopedia

The third phase of the Encyclopedia of DNA Elements (ENCODE) project has generated the most comprehensive catalogue yet of the functional elements that regulate our genes.
By
  1. Chung-Chau Hon

    1. Chung-Chau Hon is at the RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.

  2. Piero Carninci

    1. Piero Carninci is at the RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.

Less than 2% of the human genome encodes proteins1. A grand challenge for genomic sciences has been mapping the functional elements — the regions that determine the extent to which genes are expressed — in the remaining 98% of our DNA. The Encyclopedia of DNA Elements (ENCODE) project, among other large collaborative efforts2–4, was established in 2003 to create a catalogue of these functional elements and to outline their roles in regulating gene expression. In nine papers in Nature5–13, the ENCODE consortium delivers the third phase of its valuable project.

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Nature 583, 685-686 (2020)

doi: https://doi.org/10.1038/d41586-020-02139-1

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