Figure 2: Analysis of testis biopsy samples from IV-1 (family 1) and a normal control. | Genetics in Medicine

Figure 2: Analysis of testis biopsy samples from IV-1 (family 1) and a normal control.

From: Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans

Figure 2: Analysis of testis biopsy samples from IV-1 (family 1) and a normal control.

(a,b) Hematoxylin and eosin staining of cross-sections of a single seminiferous tubule at 400 × using testicular biopsy sample for (a) IV-1 from family 1 and (b) a normal control (NC). (c,d) Detection of haploid spermatids using fluorescence in situ hybridization (FISH) with probes for chromosome 18 (white), chromosome X (red), and chromosome Y (green), showing microscopic pictures of cross-sections of a single seminiferous tubule from (c) the patient and (d) a normal control. Haploid spermatids were those with a white dot and either a green or red dot but not both. Red arrow, haploid spermatid.

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