Table 2 Independent associations between markers of vascular alterations and leptin
From: Leptin links with plasminogen activator inhibitor-1 in human obesity: the SABPA study
Lean | Obese | |||||
|---|---|---|---|---|---|---|
PAI-1, ng mmol −1 | vWF, % | ACR, mg mmol −1 | PAI-1, ng mmol −1 | vWF, % | ACR, mg mmol −1 | |
R2 | 0.526 | 0.399 | 0.454 | 0.440 | 0.422 | 0.449 |
Adjusted R2 | 0.469 | 0.325 | 0.388 | 0.413 | 0.392 | 0.423 |
Std ß (95% CI) | Std ß (95% CI) | Std ß (95% CI) | Std ß (95% CI) | Std ß (95% CI) | Std ß (95% CI) | |
Leptin, ng ml−1 | 0.028 (−0.199 to 0.255) | 0.143 (−0.1818 to −0.404) | −0.062 (−0.307 to –0.183) | 0.293 (0.109–0.477)‡ | 0.091 (−0.097 to −0.279) | 0.129 (−0.051–0.309) |
Ethnicity (0,1) | −0.648 (−0.852 to −0.444)§ | −0.553 (−0.786 to −0.320)§ | −0.609 (−0.830 to −0.388)§ | −0.539 (−0.662 to −0.416)§ | −0.656 (−0.783 to −0.529)§ | −0.483 (−0.605–−0.361)§ |
Gender (0,1) | −0.162 (−0.294 to 0.030) | 0.177 (−0.121 to 0.475) | 0.262 (−0.018 to 0.542) | −0.258 (−0.430 to −0.086)‡ | 0.029 (−0.149 to 0.207) | 0.062 (−0.109 to 0.253) |
Age, years | 0.025 (−0.124 to 0.174) | 0.094 (−0.078 to 0.266) | 0.293 (0.130 to 0.456)§ | −0.028 (−0.124 to 0.068) | 0.099 (−0.003 to 0.201) | 0.113 (0.017 to 0.209)‡ |
WHtR | −0.045 (−0.204 to 0.114) | −0.024 (−0.208 to 0.160) | −0.116 (−0.288 to 0.056) | −0.085 (−0.205 to 0.035) | −0.043 (−0.166 to 0.080) | −0.035 (−0.153 to 0.083) |
24 h SBP, mmHg | 0.036 (−0.127 to 0.199) | 0.045 (−0.141 to 0.231) | 0.137 (−0.037 to 0.311) | −0.036 (−0.142 to 0.070) | 0.005 (−0.105 to 0.115) | 0.211 (0.107 to 0.315)§ |
TC:HDL, mmol l−1 | 0.043 (−0.131 to 0.263) | 0.026 (−0.174 to 0.226) | 0.003 (−0.185 to 0.191) | 0.007 (−0.099 to 0.113) | 0.038 (−0.072 to 0.148) | −0.092 (−0.198 to 0.014) |
Serum glucose, mmol l−1 | −0.017 (−0.184 to 0.150) | 0.071 (−0.119 to 0.261) | −0.139 (−0.319 to 0.041) | 0.174 (0.072 to 0.276)§ | 0.018 (−0.086 to 0.122) | −0.014 (−0.114 to 0.086) |
C−reactive protein, mg l−1 | −0.001 (−0.152 to 0.149) | 0.003 (−0.172 to 0.177) | 0.047 (−0.118 to 0.212) | −0.099 (−0.217 to 0.019) | 0.138 (0.016 to 0.259)† | 0.009 (−0.109 to 0.127) |
Smoking (0,1) | 0.020 (−0.121 to 0.161) | −0.064 (−0.225 to 0.097) | −0.096 (−0.247 to 0.055) | 0.039 (−0.057 to 0.135) | −0.013 (−0.111 to 0.085) | −0.011 (−0.105 to 0.083) |
GGT, U l−1 | −0.018 (−0.216 to 0.180) | 0.131 (−0.096 to 0.358) | −0.005 (−0.219 to 0.209) | 0.082 (−0.034 to 0.198) | −0.090 (−0.210 to 0.030) | −0.096 (−0.210 to 0.018) |
Physical activity (0,1,2) | −0.046 (−0.187 to 0.095) | 0.081 (−0.082 to 0.244) | 0.097 (−0.056 to 0.250) | −0.046 (−0.138 to 0.046) | 0.012 (−0.084 to 0.108) | −0.045 (−0.137 to 0.047) |
Anti−hypertensive medication (0,1) | 0.036 (−0.105 to 0.177) | −0.086 (−0.247 to 0.075) | 0.046 (−0.107 to 0.199) | 0.057 (−0.041 to 0.155) | 0.047 (−0.055 to 0.149) | −0.075 (−0.171 to 0.021) |
