Abstract
Three new glycosylated phenazine derivatives, named izuminosides A–C (1–3) have been isolated from the ethyl acetate extract of Streptomyces sp. IFM 11260. The structures of the new compounds were determined on the basis of their spectral data. Compounds 1–3 were evaluated for their activity in overcoming tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma cells. Compounds 2 (10 μM) and 3 (60 μM) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistance AGS cells.
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Acknowledgements
We are thankful to Professor Tohru Gonoi (Medical Mycology Research Center, Chiba University) for the identification of Streptomyces sp. IFM 11260. The research was supported by Grant in-Aid for Scientific Reserch from the Japan Society for the Promotion of Science, and MS Abdelfattah thanks JSPS for a postdoctoral fellowship (ID No. P09042).
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Abdelfattah, M., Toume, K. & Ishibashi, M. Isolation and structure elucidation of izuminosides A–C: a rare phenazine glycosides from Streptomyces sp. IFM 11260. J Antibiot 64, 271–275 (2011). https://doi.org/10.1038/ja.2010.172
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DOI: https://doi.org/10.1038/ja.2010.172
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