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References
Wang, H., Sivonen, K. & Fewer, D. P. Genomic insights into the distribution, genetic diversity and evolution of polyketide synthases and nonribosomal peptide synthetases. Curr. Opin. Genet. Dev. 35, 79–85 (2015).
Sundaram, S. & Hertweck, C. On-line enzymatic tailoring of polyketides and peptides in thiotemplate systems. Curr. Opin. Chem. Biol. 31, 82–94 (2016).
Du, L. & Shen, B. Biosynthesis of hybrid peptide-polyketide natural products. Curr. Opin. Drug Discov. Dev. 4, 215–228 (2001).
Du, L., Sanchez, C. & Shen, B. Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules. Metab. Eng. 3, 78–95 (2001).
Du, L. et al. Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules. Genet. Eng. (NY) 25, 227–267 (2003).
Fischbach, M. A. & Walsh, C. T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem. Rev. 106, 3468–3496 (2006).
Dahn, U. et al. Stoffwechselprodukte von mikroorganismen. 154. Mitteilung. Nikkomycin, ein neuer hemmstoff der chitinsynthese bei pilzen. Arch. Microbiol. 107, 143–160 (1976).
Laiple, K. J., Hartner, T., Fiedler, H. P., Wohlleben, W. & Weber, T. The kirromycin gene cluster of Streptomyces collinus Tu 365 codes for an aspartate-alpha-decarboxylase, KirD, which is involved in the biosynthesis of the precursor beta-alanine. J. Antibiot. (Tokyo) 62, 465–468 (2009).
Musiol, E. M. et al. Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKS. Chem. Biol. 18, 438–444 (2011).
Weber, T. et al. Molecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moiety. Chem. Biol. 15, 175–188 (2008).
Wax, R., Maises, W., Weston, R. & Birnbaum, J. Efrotomycin, a new antibiotic from Streptomyces lactamdurans. J. Antibiot. (Tokyo) 29, 670–673 (1976).
Maehr, H., Leach, M., Williams, T. H. & Blount, J. F. The chemistry of aurodox and related antibiotics. Can. J. Chem. 58, 501–526 (1980).
Zimmerman, S. B., Chalmers, J. H. Jr . Dewey, R. S., Stapley, E. O. & Hernandez, S. Heneicomycin, a new antibiotic (A21A): fermentation, isolation, and antibacterial spectrum. J. Antibiot. (Tokyo) 32, 665–666 (1979).
Gullo, V. P. et al. Factumycin, a new antibiotic (A40A): fermentation, isolation and antibacterial spectrum. J. Antibiot. (Tokyo) 35, 1705–1707 (1982).
Thein-Schranner, I., Zahner, H., Hoppe, H. U., Hummel, I. & Zeeck, A. Metabolic products of microorganisms. 209 Kirrothricin, a new member of the kirromycin-group. J. Antibiot. (Tokyo) 35, 948–956 (1982).
Kempf, A. J. et al. L-681,217, a new and novel member of the efrotomycin family of antibiotics. J. Antibiot. (Tokyo) 39, 1361–1367 (1986).
Barbe, V. et al. Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites. J. Bacteriol. 193, 5055–5056 (2011).
McDonald, L. A., Lotvin, J. A., Bailey, A. E. & Carter, G. T. Biosynthesis of ganefromycin: results from blocked mutants and bioconversion experiments. J. Nat. Prod. 61, 217–226 (1998).
Blin, K. et al. antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 41, W204–W212 (2013).
Kodani, S., Murao, A., Hidaki, M., Sato, K. & Ogawa, N. Isolation and structural determination of a new macrolide, makinolide, from the newly isolated Streptomyces sp. MK-30. J. Antibiot. (Tokyo) 65, 331–334 (2012).
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This study was supported by the Japan Society for the Promotion of Science by Grants-in-aids (grant number 25350964).
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Sugai, S., Komaki, H., Hemmi, H. et al. Isolation and structural determination of a new antibacterial compound demethyl-L-681,217 from Streptomyces cattleya. J Antibiot 69, 839–842 (2016). https://doi.org/10.1038/ja.2016.53
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DOI: https://doi.org/10.1038/ja.2016.53
