Abstract
Hymerhabdrin A (1), a diterpenoid possessing a novel 6/6/5 fused-ring skeleton, together with four known sterols were isolated from an intertidal marine sponge Hymerhabdia sp. Their structures were elucidated by extensive spectroscopic methods, and the relative and absolute configurations of 1 were determined by NOESY analysis and electronic circular dichrosim calculations, respectively. Hymerhabdrin A (1) exhibited significant antifouling activity against Balanus amphitrite larval with LC50 (lethal concentration 50) value of 3.6 μg ml−1.
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Acknowledgements
This work was financially supported by the National Natural Science Foundation of China (No. 21202198). We thank Professor Jin-He Li, Institute of Oceanology, Chinese of Academy of Sciences, for identifying the sponge.
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Fang, ST., Yan, BF., Yang, CY. et al. Hymerhabdrin A, a novel diterpenoid with antifouling activity from the intertidal sponge Hymerhabdia sp.. J Antibiot 70, 1043–1046 (2017). https://doi.org/10.1038/ja.2017.109
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DOI: https://doi.org/10.1038/ja.2017.109
