Abstract
Several genetic loci (JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, ADAMTS9, VEGFA and HHEX-IDE) were identified to be significantly related to the risk of type 2 diabetes and quantitative metabolic traits in European populations. Here, we aimed to evaluate the impacts of these novel loci on type 2 diabetes risk in a population-based case–control study of Han Chinese (1912 cases and 2041 controls). We genotyped 13 single-nucleotide polymorphisms (SNPs) in/near these genes and examined the differences in allele/genotype frequency between cases and controls. We found that both IDE rs11187007 and HHEX rs1111875 were associated with type 2 diabetes risk (for both variants: odds ratio (OR)=1.15, 95% confidence interval (CI) 1.04–1.28, P=0.009). In a meta-analysis where we pooled our data with the three previous studies conducted in East Asians, we found that the variants of JAZF1 rs864745 (1.09 (1.03–1.16); P=3.49 × 10−3) and TSPAN8/LGR5 rs7961581 (1.11(1.05–1.17); P=1.89 × 10−4) were significantly associated with type 2 diabetes risk. In addition, the meta-analysis (7207 cases and 8260 controls) also showed that HHEX rs1111875 did have effects on type 2 diabetes in Chinese population (OR=1.15(1.10–1.21); P=1.93 × 10−8). This large population-based study and meta-analysis further confirmed the modest effects of the JAZF1, TSPAN8/LGR5 and HHEX-IDE loci on type 2 diabetes in Chinese and other East Asians.
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Acknowledgements
We thank the individuals who participated in the present study. This work was supported by grants from the National Key Technology R&D Program (2006BAI05A05), the S973 Program (2006CB910601, 2007CB947300, 2010CB529600), 863 Program (2006AA02A407), the National Natural Science Foundation of China (30972529), the Opening Project of Shanghai Key Laboratory of Complex Prescription (07DZ22917), the Shanghai–Unilever Research and Development Fund (06SU07007), the Shanghai Leading Academic Discipline Project (B205), the Chinese Nutrition Society (05015), the Shanghai Municipality Science & Technology Commission (05JC14090) and the Chinese Academy of Sciences (KSCX2-YW-R-01).
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Zhou, Dz., Liu, Y., Zhang, D. et al. Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese. J Hum Genet 55, 810–815 (2010). https://doi.org/10.1038/jhg.2010.117
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DOI: https://doi.org/10.1038/jhg.2010.117
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