Abstract
Severe acne presents sexual dimorphism in its incidence in Chinese population. It is more prevalent in males. To assess the possible Y chromosomal contribution to severe acne risk in Han Chinese males, we analyzed 2041 Y chromosomal SNPs (Y-SNPs) in 725 severe acne cases and 651 controls retrieved from our recent genome-wide association study data. After data filtering, we assigned 585 cases and 494 controls into 12 Y chromosomal haplogroups based on 307 high-confidence Y-SNPs. No statistically significant difference in the distribution of Y chromosomal haplogroup frequencies was observed between the case and control groups. Our results showed a lack of association between the incidence of severe acne and the different Y chromosomal haplogroup in the Han Chinese population.
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Acknowledgements
We are grateful to all the volunteers and samplers. This study was supported by grants from the National Natural Science Foundation of China (81060123, 81360234), the Yunnan Natural Science Foundation (2011FA028, 2011FB175, 2012FB004) and R&D Infrastructure and Facility Development Program of Yunnan Province (2011-307). The Youth Innovation Promotion Association, Chinese Academy of Sciences, provided support to M-SP.
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Guo, MH., Wu, WJ., Fan, L. et al. No association between Y chromosomal haplogroups and severe acne in the Han Chinese population. J Hum Genet 59, 475–476 (2014). https://doi.org/10.1038/jhg.2014.53
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DOI: https://doi.org/10.1038/jhg.2014.53
