Abstract
The relationship between oncogenic human papillomavirus (HPV) infection and later cytological findings in the uterine cervix is unknown in women who were negative for intraepithelial lesion and malignancy (NILM) or atypical squamous cells of undetermined significance (ASC-US). This was investigated in this study in a Japanese population to determine the clinical utility of oncogenic (HPV) genotyping. The relative risk of progressive cytological findings 2 years after identification of oncogenic HPV infection was higher than in cases of non-oncogenic HPV infection (relative risk 3.827; 95% confidence interval (CI): 1.282–11.422), as well as in cases of negative HPV infection (relative risk 2.124; 95% CI: 1.451–3.110). Moreover, the relative risk of progression of cytological findings 2 years later in cases of HPV-16 infection was higher than in cases of HPV-52 infection (relative risk 2.094; 95% CI: 1.005–3.935). Therefore, the initial HPV-DNA genotype may be a potential predictive marker of later progression of cytological findings in the uterine cervix in cases of NILM or ASC-US.
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Acknowledgements
This work was supported by the Japan Society for the Promotion of Science KAKENHI, grant numbers 23592406 and 24791712. We thank Makoto Murakami, Masaki Fuse, Tetsuro Samejima, Akira Fujishita, Daisuke Nakayama, Kohei Kotera and Yasuko Noguchi for their assistance in this study.
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Abe, S., Miura, K., Kinoshita, A. et al. Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US. J Hum Genet 59, 251–255 (2014). https://doi.org/10.1038/jhg.2014.9
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DOI: https://doi.org/10.1038/jhg.2014.9
