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Rodent Quality Assurance Testing: Use of Sentinel Animal Systems

Lab Animal volume 32, pages 36–43 (2003)Cite this article

Abstract

The ability to produce unique strains of genetically engineered mice has revolutionized biomedical research, but has also complicated the maintenance of “clean” facilities through an increase in the movement of animals between facilities and the production of immunodeficient strains. The authors discuss the use of sentinel and quarantine programs to minimize disease transmission between laboratory mice.

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References

  1. Hogan, B., Costantini, F. & Lacy, E. Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1986).

    Google Scholar 

  2. Dick, E.J. Jr., et al. Mousepox outbreak in a laboratory mouse colony. Lab. Anim. Sci. 46, 602–611 (1996).

    PubMed  Google Scholar 

  3. Lipman, N.S., Perkins, S., Nguyen, H., Pfeffer, M. & Meyer, H. Mousepox resulting from use of ectromelia virus-contaminated, imported mouse serum. Comp. Med. 50, 426–435 (2000).

    CAS  PubMed  Google Scholar 

  4. Lipman, N.S. Isolator rodent caging systems (state of the art): a critical view. Contemp. Top. Lab. Anim. Sci. 38, 9–17 (1999).

    PubMed  Google Scholar 

  5. Committee on Infectious Diseases of Mice and Rats, Institute of Laboratory Animal Resources, National Research Council. Infectious Diseases of Mice and Rats (National Academy Press, Washington, DC, 1991).

  6. Lipman, N.S. & Perkins, S.E. in Laboratory Animal Medicine 2nd edn. (eds. Fox, J.G., Anderson, L.C., Loew, F.M. & Quimby, F.W.) 1143–1184 (Academic Press, San Diego, CA, 2002).

    Book  Google Scholar 

  7. Nicklas, W. et al. Implications of infectious agents on results of animal experiments. Lab. Anim. 33, S1:39–S1:87 (1999).

    Google Scholar 

  8. Baker, D.G. Natural pathogens of laboratory mice, rats, and rabbits and their effects on research. Clin. Microbiol. Rev. 11, 231–266 (1998).

    Article  CAS  Google Scholar 

  9. Shek, W.R. & Gaertner, D.J. in Laboratory Animal Medicine 2nd edn. (eds. Fox, J.G., Anderson, L.C., Loew, F.M. & Quimby, F.W.) 365–393 (Academic Press, San Diego, CA, 2002).

    Book  Google Scholar 

  10. Rehg, J.E. & Toth, L.A. Rodent quarantine programs: purpose, principles, and practice. Lab. Anim. Sci. 48, 438–447 (1998).

    CAS  PubMed  Google Scholar 

  11. Nicklas, W. et al. Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab. Anim. 36, 20–42. (2002).

    Article  CAS  Google Scholar 

  12. Koszdin, K.L. & DiGiacomo, R.F. Outbreak: detection and investigation. Comp. Med. 41, 18–27 (2002).

    CAS  Google Scholar 

  13. Otto, G. & Tolwani, R.J. Use of microisolator caging in a risk-based mouse import and quarantine program: a retrospective study. Contemp. Top. Lab. Anim. Sci. 41, 20–27 (2002).

    PubMed  Google Scholar 

  14. Parker, J.C. in The Mouse in Biomedical Research Vol. 2 (eds. Foster, H.L., Small, J.D. & Fox, J.G.) 107–152 (Academic Press, New York, 1982).

    Google Scholar 

  15. Gibson, S.V., Waggie, K.S., Wagner, J.E. & Ganaway, J.R. Diagnosis of subclinical Bacillus piliformis infection in a barrier-maintained mouse production colony. Lab. Anim. Sci. 37, 786–788 (1987).

    CAS  PubMed  Google Scholar 

  16. Homberger, F.R. Maternally-derived passive immunity to enterotropic mouse hepatitis virus. Arch. Virol. 122, 133–141 (1992).

    Article  CAS  Google Scholar 

  17. Hansen, A.X. Improvement of health monitoring and the microbiological quality of laboratory rats. Scand. J. Lab. Anim. Sci. 23 (Suppl. 2), 1–70 (1996).

    Google Scholar 

  18. Besselsen, D.G., Wagner, A.M. & Loganbill, J.K. Effect of mouse strain and age on detection of mouse parvovirus 1 by use of serologic testing and polymerase chain reaction analysis. Comp. Med. 50, 489–502 (2000).

    Google Scholar 

  19. Jacoby, R.O. & Lindsey, J.R. Risks of infection among laboratory rats and mice at major biomedical research institutions. ILAR J. 39, 266–271 (1998).

    Article  Google Scholar 

  20. Livingston, R.S. & Riley, L.K. Diagnostic testing of mouse and rat colonies for infectious agents. Lab Anim. (NY) 32, 46–53 (2003).

    Article  Google Scholar 

  21. Smith, A.L. An immunofluorescence test for detection of serum antibody to rodent coronaviruses. Lab. Anim. Sci. 33, 157–160 (1983).

    CAS  PubMed  Google Scholar 

  22. Dillehay, D.L., Lehner, N.D. & Huerkamp, M.J. The effectiveness of a microisolator cage system and sentinel mice for controlling and detecting MHV and Sendai virus infections. Lab. Anim. Sci. 40, 367–370 (1990).

    CAS  PubMed  Google Scholar 

  23. Cundiff, D.D., Riley, L.K., Franklin, C.L., Hook, R.R. Jr. & Besch-Williford, C. Failure of a soiled bedding sentinel system to detect ciliary associated respiratory bacillus infection in rats. Lab. Anim. Sci. 45, 219–221 (1995).

    CAS  PubMed  Google Scholar 

  24. Artwohl, J.E., Cera, L.M., Wright, M.F., Medina, L.V. & Kim, L.J. The efficacy of a dirty bedding sentinel system for detecting Sendai virus infection in mice: a comparison of clinical signs and seroconversion. Lab. Anim. Sci. 44, 73–75 (1994).

    CAS  PubMed  Google Scholar 

  25. Institute of Laboratory Animal Resources. Long-term holding of laboratory rodents. A report of the Committee on Long-Term Holding of Laboratory Rodents. ILAR News 19, L1–L25 (1976).

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Authors and Affiliations

  1. Research Animal Resource Center, Memorial Sloan-Kettering Cancer Center and the Weill Medical College of Cornell University, 1275 York Ave., New York, 10021, NY

    Neil S. Lipman VMD & Felix R. Homberger DVM, PhD

Authors
  1. Neil S. Lipman VMD
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  2. Felix R. Homberger DVM, PhD
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Corresponding author

Correspondence to Neil S. Lipman VMD.

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Lipman, N., Homberger, F. Rodent Quality Assurance Testing: Use of Sentinel Animal Systems. Lab Anim 32, 36–43 (2003). https://doi.org/10.1038/laban0503-36

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