Figure 1 | Laboratory Investigation

Figure 1

From: Induction of liver fibrosis in a murine hepatoma model by thioacetamide is associated with enhanced tumor growth and suppressed antitumor immunity

Figure 1Figure 1

Liver fibrosis induction enhances hepatoma cell growth. Intra-spleen inoculation of ML-1 established tumor nodule formation in the liver of BALB/c mice. TAA was used to induce fibrosis. The protocol of dose and timing was as indicated. (a) TAA injection after ML-1 implantation represents fibrosis induction after tumor growth (ML1–TAA). (b) TAA injection before ML1 implantation represents tumor growth after fibrosis (TAA–ML1). (c) TAA continuing treatment is the combination of the two above (TAA–ML1–TAA). Each group contains at least five mice, three of each experiment were repeated with similar results. (d) The representative hepatoma tumor nodules for model A in ML1-bearing mice (ML1) or ML-1 growth in fibrotic liver (ML1–TAA).

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