Figure 2
The microbiome of caspase-11−/− mice contains reduced Prevotellacea, but this is not associated with their hypersensitivity towards dextran sodium sulfate (DSS)–induced colitis. Expression of the microbial phyla (a) Prevotellacea and (b) Bacteroides in the fecal samples of separately housed C57BL/6J and caspase-11−/− (C11−/−) mice before (day 0) and 10 days after the start of 2% DSS administration. Data depict the mean±s.d. (n=6 per group). Expression of the microbial species (c) Prevotellaceae and (d) Bacteroides in the fecal samples of C57BL/6J and C11−/− mice that were first co-housed together for 4 weeks (day 0) and then induced with 2% DSS (day 10). Data depict the mean±s.d. (n=12 per group). (e) The percentage of body weight, (f) the clinical score, (g) macroscopic pictures and (h) graphic presentation of the colon length of C57BL/6J and C11−/− mice that were co-housed together for 4 weeks and afterwards induced with 2% DSS. Data depict the mean±s.e.m. (e,f; n=12 per group) or individual replicates with mean (h; n=12 per group). Statistical significance between DSS-treated C57BL/6J and C11−/− mice is indicated. *P<0.05; **P<0.01; ***P<0.001. n.s., not significant.
