Figure 8
From: Regulation of IL-12p40 by HIF controls Th1/Th17 responses to prevent mucosal inflammation
Potential role for IL-12p40 homodimer as an “inflammatory brake” during hypoxic inflammation. Activation of HIF via hypoxia or therapeutic PHDi treatment leads to a selective induction of IL-12p40 and secretion of IL-12p40 homodimer by myeloids cells, which suppress the differentiation of naive T helper cells into Th1cells or the stabilization of Th17 cells, limiting the progression of Th1/th17 inflammation. PHDi: prolyl-hydroxylase inhibitor, Hx: hypoxia Th0: naive T helper cell. HIF, hypoxia-inducible factor-1α.
