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Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia

Molecular Psychiatry volume 18, pages 10–11 (2013)Cite this article

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Recent schizophrenia research supports a model, wherein aberrant brain changes in late-adolescence contribute to the onset and early progression of disease.1 To further examine this model, longitudinal studies of genetic high-risk subjects, including those in prodromal stage, have recently been conducted.2 Parallel studies evaluating patients with recent-onset schizophrenia are growing in number.3 Nonetheless, almost all these studies are limited to clinical and neuropsychological characterization, and to brain imaging. Therefore, the molecular mechanisms underlying these dynamic changes remain elusive.

In order to address this fundamental question with better molecular understanding, we have examined the cerebrospinal fluid (CSF) from patients with recent-onset schizophrenia (within the first five years of disease) and have compared these samples to those from age-matched healthy controls and patients with chronic schizophrenia (five or more years of schizophrenia) (Supplementary Table 1). Building on the hypothesis that oxidative stress and associated neuroinflammatory response may have a role in this dynamic process,4 we measured the levels of 14 selected molecules (Supplementary Table 2).

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Authors and Affiliations

  1. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    J M Coughlin, K Ishizuka, S I Kano, J A Edwards, F T Seifuddin, M A Shimano, E L Daley, P P Zandi, N G Cascella & A Sawa

  2. Bloomberg School of Public Health, Baltimore, MD, USA

    P P Zandi

  3. Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany

    F M Leweke

  4. Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    M G Pomper

  5. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    R H Yolken

  6. The Stanley Medical Research Institute, Chevy Chase, MD, USA

    R H Yolken

Authors
  1. J M Coughlin
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  2. K Ishizuka
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  3. S I Kano
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  4. J A Edwards
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  5. F T Seifuddin
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  6. M A Shimano
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  7. E L Daley
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  8. P P Zandi
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  9. F M Leweke
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  10. N G Cascella
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  11. M G Pomper
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  12. R H Yolken
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  13. A Sawa
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Corresponding author

Correspondence to A Sawa.

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The authors declare no conflict of interest.

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Coughlin, J., Ishizuka, K., Kano, S. et al. Marked reduction of soluble superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with recent-onset schizophrenia. Mol Psychiatry 18, 10–11 (2013). https://doi.org/10.1038/mp.2012.6

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