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A genome-wide view of antisense

Nature Biotechnology volume 21, page 492 (2003)Cite this article

To the editor:

The ability to study gene expression on a genomic scale is allowing a deeper understanding of specificity of antisense inhibition. Although concerns about nonsequence specific antisense effects have been raised1, few genome-wide studies have systematically investigated these effects. We draw readers' attention to one example from our laboratory where antisense treatment has clearly been shown to alter expression of genes that appear to have no relationship to the intended antisense-targeted gene.

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Figure 1: Molecular portrait of the prostate carcinoma reverted phenotype (reproduced from ref. 6).

References

  1. Stein, C. & Cheng, Y.-A. in Principles and Practice of Oncology. DeVita, V., Rosenberg, S., Hellman, S. (eds.) 3059–3074 (Lippincott, New York; 1997).

    Google Scholar 

  2. Agrawal, S. Trends Biotechnol. 14, 376–387 (1996).

    Article  CAS  Google Scholar 

  3. Bennett, C.F. Biochem. Pharmacol. 55, 9–19 (1998).

    Article  CAS  Google Scholar 

  4. Crooke, S. (ed.). Antisense Research and Application. (Springer, New York; 1998).

    Book  Google Scholar 

  5. Schena, M., Shalon, D., Davis, R.W. & Brown, P.O. Science 270, 467–470 (1995).

    Article  CAS  Google Scholar 

  6. Cho, Y.S. et al. Proc. Natl. Acad. Sci. USA 98, 9819–9823 (2001).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Cellular Biochemistry Section, Basic Research Laboratory, National Cancer Institute, Bethesda, MD

    Yoon S. Cho-Chung

  2. DNA Array Unit, National Institute on Aging, Baltimore, MD

    Kevin G. Becker

Authors
  1. Yoon S. Cho-Chung
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  2. Kevin G. Becker
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Cho-Chung, Y., Becker, K. A genome-wide view of antisense. Nat Biotechnol 21, 492 (2003). https://doi.org/10.1038/nbt0503-492a

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