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Reply to Toward the complete interactome

Nature Biotechnology volume 24, page 615 (2006)Cite this article

Marc Vidal and colleagues respond:

The distorting effect of limited sampling on the overall topology of interactome models, relative to the actual network they are supposed to represent, is a subject of great interest. Our paper showed that out of four different topological models examined, scale-free networks were most likely to produce scale-free samples, although we could not formally exclude any of the other models by the criteria tested. Friedel and Zimmer suggest that limited sampling not only affects the degree distribution of a network, but can also distort its average local clustering coefficient (CC)1.

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References

  1. Watts, D.J. & Stroggatz, S.H. Nature 393, 440–442 (1998).

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Authors and Affiliations

  1. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, and Department of Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Denis Dupuy, Nicolas Bertin, Michael E. Cusick & Marc Vidal

  2. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Beijing, 100101, China

    Jing-Dong J. Han

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  1. Denis Dupuy
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  2. Nicolas Bertin
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  3. Michael E. Cusick
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  4. Jing-Dong J. Han
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  5. Marc Vidal
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Dupuy, D., Bertin, N., Cusick, M. et al. Reply to Toward the complete interactome. Nat Biotechnol 24, 615 (2006). https://doi.org/10.1038/nbt0606-615a

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