Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vaccine development

NKT-cell adjuvants in conjugate

Two studies demonstrate that natural killer T-cell adjuvants, covalently attached to either carbohydrate or peptide epitopes, yield effective vaccines.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Structures of NKT-cell adjuvant-vaccine epitope conjugates.
The alternative text for this image may have been generated using AI.

References

  1. Cavallari, M. et al. Nat. Chem. Biol. 10, 950–956 (2014).

    Article  CAS  Google Scholar 

  2. Anderson, R.J. et al. Nat. Chem. Biol. 10, 943–949 (2014).

    Article  CAS  Google Scholar 

  3. Steinhagen, F., Kinjo, T., Bode, C. & Kinman, D.M. Vaccine 29, 3341–3355 (2011).

    Article  CAS  Google Scholar 

  4. Rossjohn, J., Pellicci, D.G., Patel, O., Gapin, L. & Godfrey, D.I. Nat. Rev. Immunol. 12, 845–857 (2012).

    Article  CAS  Google Scholar 

  5. Carreño, L.J., Kharkwal, S.S. & Porcelli, S.A. Immunotherapy 6, 309–320 (2014).

    Article  Google Scholar 

  6. King, I.K. et al. Nat. Immunol. 13, 44–50 (2012).

    Article  CAS  Google Scholar 

  7. Tonti, E. et al. J. Immunol. 188, 3217–3222 (2012).

    Article  CAS  Google Scholar 

  8. Astronomo, R.D. & Burton, D.R. Nat. Rev. Drug Discov. 9, 308–324 (2010).

    Article  CAS  Google Scholar 

  9. Enomoto, N. et al. J. Immunol. 188, 1734–1741 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paul B Savage.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Savage, P. NKT-cell adjuvants in conjugate. Nat Chem Biol 10, 882–883 (2014). https://doi.org/10.1038/nchembio.1667

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nchembio.1667

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing