Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Neuroinflammation

Modulating mighty microglia

Nature Chemical Biology volume 10, pages 988–989 (2014)Cite this article

Subjects

The small molecule inflachromene was discovered as a microglia-selective inhibitor of the central nervous system proinflammatory response and found to target HMGB2 and HMGB1 to impair proinflammatory signaling in microglia, resulting in neuroprotection.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: ICM protects neurons and myelin through inhibition of microglial HMGB1 and HMGB2.
The alternative text for this image may have been generated using AI.

Marina Corral Spence/Nature Publishing Group

References

  1. Block, M.L., Zecca, L. & Hong, J.S. Nat. Rev. Neurosci. 8, 57–69 (2007).

    Article  CAS  Google Scholar 

  2. Brown, G.C. & Neher, J.J. Nat. Rev. Neurosci. 15, 209–216 (2014).

    Article  CAS  Google Scholar 

  3. Perry, V.H. & Holmes, C. Nat. Rev. Neurol. 10, 217–224 (2014).

    Article  CAS  Google Scholar 

  4. Bachstetter, A.D. et al. J. Neuroscience 32, 10201–10210 (2012).

    Article  CAS  Google Scholar 

  5. Lee, S. et al. Nat. Chem. Biol. 10, 1055–1060 (2014).

    Article  CAS  Google Scholar 

  6. Harris, H.E., Andersson, U. & Pisetsky, D.S. Nat. Rev. Rheumatol 8, 195–202 (2012).

    Article  CAS  Google Scholar 

  7. Sanchez-Guajardo, V., Barnum, C.J., Tansey, M.G. & Romero-Ramos, M. ASN Neuro 5, 113–139 (2013).

    Article  CAS  Google Scholar 

  8. Sorce, S. & Krause, K.H. Antioxid. Redox Signal. 11, 2481–2504 (2009).

    Article  CAS  Google Scholar 

  9. Parkhurst, C.N. et al. Cell 155, 1596–1609 (2013).

    Article  CAS  Google Scholar 

  10. Qin, L. et al. Glia 55, 453–462 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Michelle L. Block is in the Department of Anatomy and Cell Biology, The Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.,

    Michelle L Block

Authors
  1. Michelle L Block
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Michelle L Block.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Block, M. Modulating mighty microglia. Nat Chem Biol 10, 988–989 (2014). https://doi.org/10.1038/nchembio.1691

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nchembio.1691

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research