Figure 1: SF3B1 mutations can propagate from HSCs to their progeny.
From: SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment
SF3B1 mutations occurs in rare HSC phenotypic cells, is largely maintained in more committed progenitors MPPs as well as in more differentiated progenitors GMPs and MEPs. Tables show the progenitor cell counts (events detected by the FACS during cell sorting) for each patient sample. The average sequencing coverage across all amplicons was ≥800 reads. Bar charts indicate the SF3B1 MAB for the respective cell fraction. MAB for each cell population was confirmed by independent PCRs. MAB mutant allele burden (t-test P value>0.05).
