Figure 2: Non-CG DNA methylation profiles can separate LDC from HDC hiPSCs. | Nature Communications

Figure 2: Non-CG DNA methylation profiles can separate LDC from HDC hiPSCs.

From: Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

Figure 2

Unsupervised hierarchical clustering using non-CG methylation data revealed distinct separation of LDC from HDC hiPSCs, as well as from donor cell lines (top annotation bar). The heatmap shows the range of non-CG β-values for each sample and illustrates the tendency towards hypermethylation in HDC hiPSCs compared with that in LDC hiPSCs; donor cell lines are characterized by distinctly unmethylated non-CG domains.

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