Figure 1: Histological and immunohistochemical findings in 1HR1H4 mutant livers.
From: Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis
Expression of BSEP, MDR3 and FXR in liver (diaminobenzidine chromogen and hematoxylin counterstain) in patients with NR1H4-related cholestasis; normal controls in insets. Hematoxylin/eosin views for orientation. Original magnification, all images, × 200. BSEP and FXR are absent in all four patients when compared with positive control (inset). MDR3 is present in all four patients although reduced in patients 2 and 4. H&E, hematoxylin and eosin.
