Figure 7: KRT14pos cells are the cells of origin of bladder cancer. | Nature Communications

Figure 7: KRT14pos cells are the cells of origin of bladder cancer.

From: KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Figure 7

(a) IF on bladders from untreated control 8-month-old mouse. (b) Widespread carcinoma in situ (CIS) in the bladder of a 6-month-old mouse treated with BBN for 4 months, showing remarkable KRT14pos cell population expansion, and extensive KRT14 and KRT5 colocalisation. (c) Invasive urothelial carcinoma (UC) in the bladder of an 8-month-old mouse treated with BBN for 6 months, showing extensive colocalisation of KRT14 and KRT5. (d-i) Krt14CreERT2/+;R26tdTomato/+ mice treated with tamoxifen before BBN treatment for 4 (d,f) or 6 months (e,g-i) showing variable histological abnormalities and cytokeratin profile. Stars designate the bladder lumen. Scale bars, 100 μm.

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