Figure 2: Structure of the RanGTP·Xpo4·eIF5A export complex and HEAT repeat organization of Xpo4. | Nature Communications

Figure 2: Structure of the RanGTP·Xpo4·eIF5A export complex and HEAT repeat organization of Xpo4.

From: Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A

Figure 2

(a) Xpo4 (grey) is shown as surface representation, while Ran (green) and eIF5A are shown as ribbon representation. Different regions of eIF5A are coloured and labelled accordingly. GTP is shown as black sticks. (b) Xpo4 in the export complex is shown in a ribbon representation (RanGTP and eIF5A are removed for clarity). Colour scheme: A helices of the HEAT repeats, blue; B helices, yellow; long inter-repeat insertions, dark pink; the acidic loop, brown. (c) Schematic representation of the Xpo4 secondary structure. Colouring is as in b. Green and orange dots represent the Xpo4 residues interacting with RanGTP and eIF5A, respectively.

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