Figure 1: Genetic comparison of immunoglobulin heavy chain constant regions (CH) of AGM, RM and human.

(a) Number of immunoglobulin CH isotype genes identified in AGM (n=6), RM (n=8) and human (n=9). (b) Joint radial phylogenic tree of AGM (red lines), RM (orange lines) and human (blue lines) CH genes. Ten RM IgA intra-species heterogenetic alleles were listed in the radial tree. (c) Rectangular phylogenic tree of AGM, RM and human IgG subclass CH genes, demonstrating greater homology of AGM CH genes to that of RM than human.