Table 2 Fourteen novel loci reaching genome-wide significance in two-stage GWAS of BCC.
From: Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma
SNP | Region | Gene | Maj/min | MAF (avg imp r2) | P | OR | P | OR | P | OR |
|---|---|---|---|---|---|---|---|---|---|---|
rs2116709 | 3p13 | FOXP1 | A/T | 0.40 (0.91) | 7.9 × 10−15 | 0.89 | 6.1 × 10−4 | 0.91 | 2.3 × 10−17 | 0.90 |
rs10810657 | 9p22.2 | BNC2 | A/T | 0.41 (0.98) | 5.1 × 10−14 | 0.90 | 5.7 × 10−5 | 0.90 | 1.5 × 10−17 | 0.90 |
rs191177147 | 3q28 | LPP | G/T | 0.39 (0.80) | 3.2 × 10−12 | 1.11 | 1.0 × 10−3 | 1.10 | 1.2 × 10−14 | 1.11 |
rs9275642 | 6p21.32 | HLA-DQA2 | C/T | 0.21 (0.89) | 1.2 × 10−11 | 0.89 | 2.7 × 10−2* | 0.81 | 2.4 × 10−12 | 0.89 |
rs73183643 | 7q22.1 | CUX1 | G/A | 0.24 (0.96) | 8.5 × 10−11 | 0.90 | 2.3 × 10−4 | 0.89 | 1.5 × 10−13 | 0.90 |
rs11993814 | 8q21.13 | ZBTB10 | C/T | 0.26 (1.0) | 2.8 × 10−10 | 0.91 | 4.5 × 10−2 | 0.94 | 8.8 × 10−11 | 0.92 |
rs2776353 | 21q22.3 | LINC00111 | A/T | 0.33 (0.96) | 5.0 × 10−10 | 0.91 | 7.7 × 10−4 | 0.91 | 1.6 × 10−12 | 0.91 |
rs10425559 | 19p13.3 | PLIN3 | G/A | 0.40 (0.97) | 3.8 × 10−9 | 0.92 | 8.4 × 10−1 | 0.99 | 2.8 × 10−8 | 0.93 |
rs1050529 | 6p21.33 | HLA-B | C/T | 0.25 (0.71) | 4.6 × 10−9 | 0.90 | 2.7 × 10−1† | 0.89 | 2.6 × 10−9 | 0.90 |
rs7776701 | 7p12.3 | TNS3 | C/T | 0.48 (0.98) | 5.3 × 10−9 | 0.93 | 5.1 × 10−1 | 0.98 | 4.2 × 10−8 | 0.94 |
rs9267650 | 6p21.3 | NEU1 | A/T | 0.05 (0.98) | 2.4 × 10−8 | 1.18 | 2.0 × 10−1 | 1.09 | 1.1 × 10−8 | 1.17 |
rs7907606 | 10q24.3 | OBFC1 | T/G | 0.17 (0.96) | 7.4 × 10−8 | 1.10 | 2.4 × 10−2 | 1.08 | 4.7 × 10−9 | 1.10 |
rs4710154 | 6q27 | MIR3939 | A/T | 0.32 (0.93) | 8.1 × 10−8 | 1.08 | 4.3 × 10−2 | 1.06 | 1.1 × 10−8 | 1.08 |
rs2294214 | 6p22.3 | CASC15 | A/C | 0.32 (0.95) | 2.6 × 10−5 | 1.06 | 5.9 × 10−5 | 1.13 | 3.1 × 10−8 | 1.07 |
