Figure 4: Yki-dependent regulation of Dilp8 adjusts organ growth and limits developmental instability. | Nature Communications

Figure 4: Yki-dependent regulation of Dilp8 adjusts organ growth and limits developmental instability.

From: The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression

Figure 4

(a,c,e,g) JNK-dependent regulation of dilp8 expression is not affected in dilp8-PFΔ123 mutants. (b,d,f,h) represent higher magnification images of the area shown in the dashed lines. Wing discs were dissected from the indicated genotypes and stained for Dilp8. (i) Mutation of the three Sd-binding sites in the dilp8 promoter by gene editing induces FA. Bar histograms shows FA indices (FAi) of left and right wing areas measured on individuals of the indicated genotypes. ***P<0.0001, F-test for unequal distributions.

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