Figure 3: Impaired JAK1-mediated signalling in the patient’s fibroblasts.
From: Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection
(a,b) Primary fibroblasts from the patient or a healthy control were treated with the indicated concentrations of IFN-α (a) or IFN-γ (b) for 15 min and protein extracts were subjected to immunoblotting. Representative of three independent experiments. Fold change of band densitometry is indicated (numbers below bands and bar graphs in Supplementary Fig. 6).
