Figure 6: Model of signal transduction downstream of WSS.
From: Fluid shear stress activates YAP1 to promote cancer cell motility
Transduction of biomechanical force caused by fluid flow stimulates a signalling cascade through activation of ROCK and LIMK. Activated LIMK phosphorylates cofilin to inhibit its actin depolymerizing function. In the presence of stabilized F-actin, the cell is poised for regulation by LATS1/2. YAP1 is dephosphorylated and localizes to the nucleus to drive transactivation of gene promoters occupied by TEAD. Genes regulated downstream of YAP1 promote cell movement and survival. Although our data is consistent with LATS as a contributor to regulation, we cannot exclude alternate scenarios that include other kinases that post-transcriptionally modify YAP1.
