Figure 8: MST1 regulates IL-6 production through p38MAPK. | Nature Communications

Figure 8: MST1 regulates IL-6 production through p38MAPK.

From: Dendritic cell MST1 inhibits Th17 differentiation

Figure 8: MST1 regulates IL-6 production through p38MAPK.The alternative text for this image may have been generated using AI.

(a) Intercellular staining of the indicated proteins in splenic DCs following LPS stimulation in vitro. Expression of the phosphorylation of p38MAPK (MFI) among CD11c+cells is summarized in b. (c,d) Intracellular staining of IL-6 in DC isolated from the indicated mice 4 h after the i.p. injection of 10 mg kg−1 LPS (c). Right, the proportion of IL-6+ cells in DCs is summarized. The serum IL-6 level in the indicated mice (d). (e) Intracellular staining of IL-17 and IFNγ in T cells co-cultured with splenic DCs isolated from indicated mice was determined with FCM. Right, proportion of IL-17 and IFNγ in CD4+T cells is summarized. (f) Expression of the indicated gene in T cells was determined with FCM and the MFI summarized. Data are representative of four independent experiments (mean±s.d.; n=3–5). *P<0.05, **P<0.01 and ***P<0.001, compared with the indicated groups. P-values were determined using Student’s t-tests.

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