Figure 2: Haematopoietic and non-haematopoietic stromal components are required for tumour rejection. | Nature Communications

Figure 2: Haematopoietic and non-haematopoietic stromal components are required for tumour rejection.

From: Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

Figure 2: Haematopoietic and non-haematopoietic stromal components are required for tumour rejection.

BM chimeras (8–14 weeks old) were generated via irradiation of recipient mice and subsequent BM transfer from donor mice 1 day later. WT mice received BM from Tlr3/7/9−/− mice to generate chimera 1 (dark green). To generate chimera 2 (light green), Tlr3/7/9−/− mice received WT BM. As a control, irradiated WT mice received WT BM (black) and Tlr3/7/9−/− mice received TLR-deficient BM (blue) (n=10–12). Eight weeks later, MOPC cells were injected s.c. and tumour take (number of mice with palpable tumour) was recorded (a). Tumour volume 30 days after tumour injection of individual mice and mean (horizontal line)±s.e.m. are shown; P-value (analysis of variance) is indicated (b). Results were considered significant at *P⩽0.05 and *** P⩽0.0005.

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