Figure 6: Acute treatment of stevioside lowers the glycaemia of WT mice during a GTT in a β-cell-dependent way. | Nature Communications

Figure 6: Acute treatment of stevioside lowers the glycaemia of WT mice during a GTT in a β-cell-dependent way.

From: Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Figure 6: Acute treatment of stevioside lowers the glycaemia of WT mice during a GTT in a β-cell-dependent way.

(a–f) Results of crossover tandem GTTs performed on the same mice with a 2 week interval. Mice received either 0.5 mg g−1 stevioside applied per os 2 h before the GTT, or vehicle. Individual points represent the average±s.e.m. and the significances are the result of a paired sample t-test of the values at the same time point; non-significant differences are not indicated. (a) WT mice on a normal diet, (b) Trpm5−/− mice on a normal diet, (c) WT mice 20 weeks on a HFD, (d) Trpm5−/− mice 20 weeks on a HFD, (e) WT mice with WT islets transplanted under the kidney capsule and (f) WT mice with Trpm5−/− islets transplanted under the kidney capsule. (g) Average±s.e.m. Area under the curve (AUC) from the experiments in a–f. Paired sample t-test within groups, two-sample t-test between groups. See also Supplementary Figs 10 and 11. NS, not significant.

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